Jan Marini Skin Research, Inc. Age Intervention Face Serum
1 fl. oz. for $89
Expert Rating
Community Rating (0)Write a Review
Expert Reviews
Community Reviews
Brand Overview
Expert Reviews

Age Intervention Face Serum is a water- and oil-based serum that contains some great water-binding agents and lesser amounts of antioxidants. Although it is an option for normal to slightly dry skin, the concerns about long-term application of interferon and hormones remain. Here are the details about these controversial ingredients:

Concerning progesterone, a study published in the American Journal of Obstetrics and Gynecology (June 1999, pages 1504–1511) states that “In order to obtain the proper (effective) serum levels with use of a progesterone cream, the cream needs to have an adequate amount of progesterone in it [at least 30 milligrams per gram]. Many over the counter creams have little [for example, 5 milligrams per ounce] or none at all.” Marini does not provide information about how much progesterone her products contain.

A double-blind study involving 40 peri- and postmenopausal women using a cream containing 2% progesterone versus one without had some intriguing results: The progesterone cream showed statistically significant increases in skin firmness and elasticity compared to the control, but wrinkle depth changed little (Source: The British Journal of Dermatology, September 2005, pages 626–634). Unfortunately, the Age Intervention products with progesterone do not appear to contain anywhere close to that amount, so the same results are unlikely.

Estradiol is definitely unique to Marini products. The body produces three main forms of estrogen—estrone, estradiol, and estriol—and estradiol is the most physiologically active form. One study revealed that topical application of estradiol has photoprotective properties due to its anti-inflammatory nature, while another small-scale study showed that topical application of 0.01% estradiol had collagen-stimulating effects on postmenopausal skin (Sources: Proceedings of the National Academy of Sciences of the United States of America, August 22, 2006, pages 12837–12842; and European Journal of Obstetrics, Gynecology, and Reproductive Biology, February 2007, pages 202–205). However, as a component of estrogen, it is not without its risks and unknowns.

Decreased production of estrogen by the ovaries can lead to symptoms such as hot flashes, night sweats, vaginal dryness, urinary tract infections, depression, and irritability. Estrogen replacement can help relieve these symptoms. Although estrogen offers many benefits, it is not indicated for everyone and women should evaluate their individual risks versus benefits with their physician or health-care provider. Whether or not natural estrogens are safer than other forms has not been well-researched, and the FDA considers the claims and safety of cosmetics containing them to not be proven.

Interferon refers to any in a group of soluble glycoproteins known to have antiviral activity. Specific types of interferon include alpha interferon (the kind in this product) and gamma interferon. It is produced naturally by immune cells when the body is under attack by viruses or bacteria, and can also be delivered topically or via injection. Although interferon and its derivatives have established pharmacological benefit when applied topically, the conditions it is useful for have nothing to do with aging, at least not in terms of making skin firmer, preventing sagging, or changing hormonal levels. Further, when interferon is used via prescription, its dosage and use are scheduled and controlled. There may be risks with applying a skin-care product with an unknown amount of interferon every day.

In summation, applying hormones and interferon topically to skin is something we strongly suggest should not be taken lightly. These are not benign cosmetic ingredients, and there is limited research establishing either benefits or risks for peri- and postmenopausal skin.

Last Updated:03.25.2013
Jar Packaging:No
Tested on animals:No
Community Reviews

Age Intervention Face Serum is a breakthrough in skin rejuvenating technology created especially for adult women over the age of 25. Combines a number of agents that are specifically designed to target changes in the appearance of aging skin as a result of decreasing hormonal levels and cumulative sun exposure, and will assist in revitalizing and restoring the appearance of youthful suppleness and elasticity.


Water, Meadowfoam Seed Oil, Dimethyl Sulfone, Clover Flower Extract, Algae Extract, Sclerotium Gum, Polysorbate 20, Pregnenolone Acetate, Jojoba Seed Oil, Lecithin, Dipalmitolyl Hydroxyproline, Beta-Sitosterol, Linoleic Acid, Tocopherol, Sodium Ascorbate, Mannitol, Ubiquinone, Estradiol, Progesterone, Copper PCA, Acetic Acid, Interferon Alpha 2, Propylene Glycol, Phenoxyethanol, Methylparaben, Butylparaben, Ethylparaben, Propylparaben

Brand Overview

Jan Marini Skin Research, Inc. At-A-Glance

Strengths: Most of the products are fragrance- and colorant-free; excellent AHA and retinol options, including an AHA combined with sunscreen; the water-soluble cleansers.

Weaknesses: Expensive; some categories contain ingredients (growth factors, hormones, and interferon) with unreliable track records or whose long-term risks, if any, remain unknown; sunscreens that lack sufficient UVA-protecting ingredients; jar packaging; Marini Lash isn't as exciting as Marini’s former lash-enhancing products.

Jan Marini Skin Research, Inc., was founded, of course, by Jan Marini, who originally started out marketing products for M.D. Formulations. Thus, it isn't surprising to find that her own line is also aimed at dermatologists, aestheticians, and plastic surgeons, much the way M.D. Formulations is. In direct contrast to many of the other skin-care lines in this niche market, Marini’s line stands out with its selection of far more realistic and varied skin-care products. First, there are no spiraling-out-of-control ingredient lists where everything is thrown in except the kitchen sink. Then, and more important, you will find some well-formulated products that include sunscreens, skin-lightening options, vitamin C products, and good glycolic acid–based alpha hydroxy acid (AHA) products, along with some outstanding retinol options.

It is interesting to observe that Marini attributes the research for her "topical form of lipid (fat) soluble Vitamin C that is stable and able to be absorbed" to the form "developed in conjunction with physician researcher Nicholas Perricone, M.D." Of course, Perricone has his own version of vitamin C products, which are quite similar to Marini's in that they also contain ascorbyl palmitate. That being the case, given that he claims his are the best ever with the highest concentration of the stuff, we wonder if she would now agree with his findings? At least compared to her former partners at M.D. Formulations, Marini's information about vitamin C is more accurately based (it's backed by published research) and there's only a minimal amount of hyperbole. In fact, when it comes to the information Marini and team present to the professionals who retail their products, this line wins high marks for its close-to-accurate information about how skin ages, what can be done to minimize and prevent future signs of aging, and the effects various products have on skin. Of course, you're supposed to believe her products have all the answers, but that's what the reviews below will elucidate.

For more information about Jan Marini Skin Research, Inc., call (888) 695-2611 or visit www.janmarini.com.

About the Experts

The Beautypedia and Paula’s Choice Research teams have one mission: To help you find the best products for your skin, whether they’re from Paula’s Choice or another brand. By combining efforts, we’re able to share scientific research and remain committed to the highest standards based on our decades of experience objectively reviewing thousands upon thousands of skincare and makeup formularies in all price ranges.

Beautypedia cuts through the hype to bring you product insights and recommendations you won’t find anywhere else!