Un-Wrinkle, for All Skin Types
Un-Wrinkle, for All Skin Types, is a rose-scented serum loaded with peptides in a proportion that the company claims tops out at 23%, therefore enabling this product make dramatic anti-wrinkle claims that might have you canceling that appointment for Botox or dermal fillers. Yet there is no research showing that higher concentrations of peptides can have an effect that matches what’s possible from these in-office procedures. Below are details about the key peptides in this product.
SYNr-AKE comes from Pentapharm, whose Web site describes it as a “peptide with an Age Killing Effect. Mimics the neuromuscular blocking properties of Waglerin 1, a polypeptide found in the venom of the snake Tropidolaemus wagleri.” This snake is a type of viper, and Waglerin-1 is a peptide (composed of 22 amino acids) that is derived and purified from the venom. There is information on how this peptide performs on neurons in the brain and on its relation to GABA (gamma amino butyric acid), a common ingredient in products claiming to work like Botox. However, information on how this ingredient works when blended into cosmetic products is lacking. Waglerin-1 is said to be another blocker of the neurotransmitter acetylcholine, which triggers muscle contractions. But if it worked as claimed, when applied topically it would relax muscles in your fingers, too, and what would happen if you used too much at once or accidentally got it too near the area around your eyes or mouth? (Sources: Journal of Pharmacology and Experimental Therapeutics, July 1997, pages 74–80; and Brain Research, August 1999, pages 29–37).
The SNAP-8 peptide is said to targets the “wrinkle formation mechanism” in the same manner as Botox injections. Although there is no substantiated research to support that claim, keep in mind that not even Botox works like Botox when it’s applied topically. Fear the needle or not, if you want Botox to work it must be injected into, not dabbed on, your skin. SNAP-8 (technically acetyl octapeptide-3) is the trade name for an ingredient manufactured by Centerchem. Of course, the only efficacy studies performed for this peptide were conducted by the manufacturer, and done in vitro rather than on human skin (Source: www.centerchem.com/PDFs/SNAP-8%20Tech%20Lit%20Aug05.pdf).
Despite these seeming disappointments, peptides are exciting anti-aging ingredients that can do a lot, but they're just not capable of replacing in-office procedures regardless of the percentage a brand may tout.
The best reason to consider using this serum is the more realistic, proven benefits peptides can deliver along with the formula's antioxidants and water-binding agents, all in stable packaging. This is a costly way to get those ingredients, but they nevertheless are the most substantiated, useful ingredients in this product.
Up to a 52% reduction in wrinkle size in just 28 days. Exclusive, patent-pending blend of six powerful, 100% active WRINKLE RELAXING and ANTI-AGING PEPTIDES (highly concentrated at 23%) are combined with vitamins and skin moisturizers to create this wrinkle fighting solution with the highest degree of effective ingredients found in clinical studies. Contains the two newest peptides; SYNr-AKE at 4% (synthetic peptide which mimics snake venom activity) and SNAP-8 at 10%, a safer, pain-free alternative to the injected Botulinum Toxin that topically helps target the same wrinkle formation mechanism. SYNr-COLL at 3%, Argireline at 3% and MatrixylT 3000 (a dual peptide) at 3% complete this patent pending blend of six peptides. Helps boost natural collagen production and leaves skin looking soft, smooth and years younger.
Peter Thomas Roth At-A-Glance
Peter Thomas Roth is a large but straightforward line with mostly uncomplicated formulations that, for the most part, are quite good and state-of-the-art. Unlike many product lines, most of the acne, AHA, BHA, sunscreen, and moisturizing products contain what they should to be effective and helpful for skin.
Even more impressive are the well-formulated cleansers, sunscreens, AHA products, and skin brighteners. The moisturizers have improved somewhat, and most are now packaged so that the light- and air-sensitive ingredients remain stable. In fact, Roth's packaging deserves special mention because it is exceptionally utilitarian.
After all that glowing praise, what you should be aware of are the instances of products containing potential irritants (noted in their respective reviews) as well as the products in jar packaging that contain ingredients which are sensitive to air and light.
For more information about Peter Thomas Roth, call (800) PTR-SKIN or visit www.peterthomasroth.com.
About the Experts
The Beautypedia team consists of skin care and makeup experts personally trained by the original Cosmetics Cop and best-selling beauty author, Paula Begoun. We’re fascinated by skin care and makeup products and thrilled when they meet or exceed our expectations, but we’re also disappointed when they fail to perform as claimed, are wildly overpriced, or contain ingredients scientific research has proven can hurt skin.
Our mission has always been to help you find the best products for your skin, no matter your budget or preferences. Beautypedia’s thorough and insightful reviews cut through the hype and provide reliable recommendations for all ages, skin types, and skin tones.