Replenix Power of Three Serum

1.00 fl. oz. for $ 70.00
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Brand Overview

Replenix Power of Three Serum is the serum version of the company's Power of Three Cream, but its formula isn't quite as good. More important, because each of these products contains the same key ingredients (discussed below), you don't really need both. If Replenix had chosen different anti-aging ingredients for the Serum, it would make more sense to use it with the Cream, but as is you're better off using the Cream or the Serum with a product from another brand. (The team behind Replenix seems to think the only antioxidants worth using are green tea, caffeine, and, occasionally, resveratrol, which is like assuming that all you need to eat is spinach, salmon, and grapes—the body needs so much more than that!)

Although caffeine, resveratrol, and green tea polyphenols are good anti-aging ingredients for skin, they're no more powerful or better than lots of others. And what about the Replenix CF products from Topix, which contain green tea polyphenols and caffeine, but not resveratrol? Are they less effective because they don't have the "Power of Three"? We admit, "Power of Three" is a great name, but it doesn't really help you make an informed decision. One more point: We were wondering about their use of the ingredient name "green tea polyphenols." It is a strange term because a polyphenol is a category, not an ingredient. The polyphenol component of green tea is epigallocatechin gallate (EGCG), but that's not clear on the label. We know you can find the term on the Internet, but even Wikipedia questions the source of that term and its accuracy. This appears to be another instance where Topix is using questionable ingredient names on their label that don't really help you understand what it contains. The correct ingredient name to use for green tea polyphenols is Camellia sinensis leaf extract.

This serum's fragrance-free formula is best for normal to oily skin that's also sensitive, as claimed. It's also suitable for rosacea-prone skin. It contains several antioxidants, and the opaque pump-bottle packaging keeps them stable during use, which is always to your skin's benefit. The formula lacks the cell-communicating ingredient that the Power of Three Cream contains, and it's short on skin-identical ingredients, too, which is why it's not rated as highly as the Cream.

There is no question that you don't need to spend this much for a good serum, but it can also be said that there are serums that cost a lot more. You may want to check out the more affordable options on our list of Best Serums.

  • Fragrance-free; suitable for sensitive or rosacea-affected skin.
  • Contains some notable antioxidants.
  • Packaged to keep the antioxidants stable during use.
  • Expensive.
  • Not as well formulated as the cream version.
Jar Packaging: No
Tested on animals: Yes

Replenix Power of Three Serum contains 90% Green Tea Polyphenols, Resveratrol and Caffeine U.S.P. in a lightweight, fast-absorbing formulation build around a hyaluronic acid (humectant) base.

Purified Water, Caffeine U.S.P., Sclerotium Gum, Camellia Sinensis (Green Tea) Polyphenols, Sodium Hyaluronate, Resveratrol, Bisabolol, Cucumis Sativus (Cucumber) Fruit Extract, Chamomilla Recutita (Matricaria) Flower Extract, Glycine Soja (Soybean) Extract, Rosmarinus Officinalis (Rosemary) Leaf Extract, Glycolic Acid, Polysorbate-20, Sodium Benzoate, Tetrasodium EDTA, Phenoxyethanol.

Topix At-A-Glance

Strengths: Most of the products are fragrance-free; packaging keeps light- and air-sensitive ingredients stable during use; several good products with retinol in varying strengths; good moisturizers and cleansers; very good body lotions.

Weaknesses: Expensive; the physician allure may seem enticing, but these products do not require a doctor's visit or medical supervision; no AHA or BHA exfoliants; no viable skin-brightening options; fragrant toner; the growth factors in the Citrix serums are potentially risky ingredients.

Topix is best known for its two chief skin-care brands, Replenix and Citrix. Of the two, we're asked most often about the Replenix collection; the Citrix line is smaller and focused on anti-aging products with vitamin C. The Replenix products contain a broader range of anti-aging ingredients, such as retinol, green tea, and grape-derived resveratrol, and the claims are broader, too, so little surprise that the Replenix products appeal to more people concerned with signs of aging. Both Replenix and Citrix offer fragrance-free formulas, albeit at fairly high prices, which is typical of most physician-dispensed lines.

A chief selling point of Topix is its physician-dispensed angle, which gives the products a medical lan; in truth, however, not a single ingredient in these products is "medicinal," prescription, or exclusive to physician-sold products. That is, you don't need to see a doctor to be "prescribed" Topix products; rather, they can be obtained from several websites, no appointment necessary. The big question is whether or not you should add any Topix products to your shopping cart and the answer is "it depends."

Within the Replenix line, the most interesting products include the serums and moisturizers. Although none of them are superior to the best options available, most of them do offer good (though pricey) formulas that treat skin to a range of beneficial ingredients.

If you're keen on retinol (and it's a great anti-aging ingredient), Replenix has you covered with several serums offering different strengths of retinol. The various strengths allow you to "step up" to stronger retinol products once your skin has acclimated to the lower strengths. Although that sounds intriguing, it's not really necessary. As we explain in the reviews, more retinol is not necessarily better, and some may find the higher-strength retinol products too sensitizing, so caution is warranted. Indeed, some people cannot tolerate any amount of retinol!

The Citrix products aren't all that exciting unless you want vitamin C in every product. Although there's nothing wrong with vitamin C, it's a mistaken notion to focus on one hero ingredient because skin requires a variety of beneficial ingredients to look and act younger. Topix also adds growth factors to their Citrix serums, but these growth-factor ingredients are unproven for topical use and may present risks (we explain why in the reviews). In short, Citrix isn't all that exciting, and several of these products fall short in one way or another.

Our research revealed that Topix has some intriguing products, but, with few exceptions, there is nothing that you cannot find elsewhere for less money. It's important to let go of the notion that skin-care products sold at a doctor's office are superior to those sold elsewhere. The truth is: There are good and bad products in every retail outlet, knowing what you're buying is more important than where you're buying it or who's selling it!

For more information about Topix, call (800) 445-2595 or visit www.topixpharm.com.

About the Experts

The Beautypedia team consists of skin care and makeup experts personally trained by the original Cosmetics Cop and best-selling beauty author, Paula Begoun. We’re fascinated by skin care and makeup products and thrilled when they meet or exceed our expectations, but we’re also disappointed when they fail to perform as claimed, are wildly overpriced, or contain ingredients scientific research has proven can hurt skin.

Our mission has always been to help you find the best products for your skin, no matter your budget or preferences. Beautypedia’s thorough and insightful reviews cut through the hype and provide reliable recommendations for all ages, skin types, and skin tones.

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