Peter Thomas Roth

Peptide 21 Wrinkle Resist Serum

1.00 fl. oz. for $ 110.00
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Brand Overview

Peter Thomas Roth claims that Peptide 21 Wrinkle Resist Serum contains peptides and neuropeptides that visibly reduce the look of fine lines and wrinkles. The verdict? This formula really does have the potential to do just that, although one ingredient trips it up from being a slam-dunk recommendation.

Starting with the aesthetics, Peptide 21 Wrinkle Resist Serum has a lightweight fluid consistency that glides smoothly over skin and is compatible with any skin type. We applaud Peter Thomas Roth for putting the formula in an opaque bottle with a pump, which helps keep its delicate ingredients stable.

As for the highly extolled neuropeptides, they’re a developing area of research at the moment. More is needed to learn about their mechanism of action on skin, but there are at least a couple of studies showing they have potential to improve hydration and strengthen skin’s barrier.

What’s more impressive is the formula’s combination of tried-and-true peptides with solid research backing their ability to help skin feel firmer, improve the appearance of wrinkles, and address concerns such as uneven skin tone as claimed. We appreciate how robust the brand went in terms of giving skin multiple peptides to work with… although by our count, it’s a couple short of 21 (we reached out to the brand to confirm but haven’t heard back at this time).

Peter Thomas Roth also included additional beneficial ingredients, such as antioxidant-rich vitamins A, C and E, as well sodium hyaluronate (a form of hyaluronic acid that’s a hydration powerhouse). The natto gum they call out isn’t quite as “breakthrough” as they make it sound, but it’s promising in terms of its ability to help skin retain moisture, while providing antioxidant benefits.

So, what’s the one ingredient snafu? Fragrant rose flower water, which is the third ingredient, meaning it’s in higher concentration than the superstar ingredients you’re paying good money for. Granted, the scent is faint and rose water is not as sensitizing as rose oil, but regardless, fragrance free is the better way to go for the health of your skin (see More Info to learn why).

This comes so close to being a hands-down, great product—without the rose water out it would easily earn our top recommendation.

  • Contains numerous peptides to improve skin in a variety of ways, including addressing wrinkles.
  • Additional antioxidants and skin-replenishing ingredients round the formula out.
  • Packaged in a way to help keep the formula effective and stable during use.
  • Contains a high dose of fragrant rose water, which isn’t great for skin.

More Info:

Fragrance in skin care: Daily use of products that contain a high amount of fragrance, whether the fragrant ingredients are synthetic or natural, causes a chronic sensitizing reaction on skin.

This reaction in turn leads to all kinds of problems, including disrupting skin’s barrier, worsening dryness, increasing or triggering redness, depleting vital substances in skin’s surface, and generally preventing skin from looking healthy, smooth, and hydrated. Fragrance free is always the best way to go for all skin types.

A surprising fact: Even though you can’t always see or feel the negative effects of fragrant ingredients on skin, the damage will still be taking place, even if it’s not evident on the surface. Research has demonstrated that you don’t need to see or feel the effects of irritation for your skin to be suffering. Much like the effects from cumulative sun damage, the negative impact and the visible damage from fragrance may not become apparent for a long time.

References for this information:
Biochimica and Biophysica Acta, May 2012, pages 1410–1419
Aging, March 2012, pages 166–175
Chemical Immunology and Allergy, March 2012, pages 77–80
Experimental Dermatology, October 2009, pages 821–832
Skin Pharmacology and Physiology, 2008, pages 191–202
International Journal of Toxicology, Volume 27, 2008, Supplement, pages 1–43
Food and Chemical Toxicology, February 2008, pages 446–475
American Journal of Clinical Dermatology, 2003, pages 789–798

Jar Packaging: No
Tested on animals: Yes

This serum helps visibly reduce the look of fine lines and wrinkles. Gamma proteins harness the power of Asian natto gum, a breakthrough ingredient that helps improve the look of elasticity, radiance, uneven skin tone, and texture. This formula is also infused with squalane, a hyaluronic acid complex, and vitamins A, C, and E.

Water, Glycerin, Rosa Centifolia Flower Water, Isopropyl Myristate, Squalane, Mannitol, Butylene Glycol, Natto Gum, Tripeptide-10 Citrulline, Acetyl Octapeptide-3, Palmitoyl Hexapeptide-12, Acetyl Tetrapeptide-11, Acetyl Hexapeptide-8, Acetyl Hexapeptide-1, Palmitoyl Oligopeptide, Acetyl Tetrapeptide-9, Acetyl Tetrapeptide-2, Tripeptide-1, Palmitoyl Tetrapeptide-7, Hexapeptide-11, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Palmitoyl Tripeptide-5, Trifluoroacetyl Tripeptide-2, Palmitoyl Tripeptide-1, Sodium Polyglutamate, Sodium Hyaluronate, Tocopheryl Acetate, Retinyl Palmitate, Ascorbic Acid, Hydrolyzed Soy Protein, Hydrolyzed Wheat Protein, Lecithin, Pseudoalteromonas Ferment Extract, Acrylates Copolymer, Magnesium Chloride, Polysorbate 20, Dimethyl Isosorbide, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Leuconostoc/Radish Root Ferment Filtrate, PEG-8 Dimethicone, Disodium Phosphate, Carbomer, Dextran, Sodium Lactate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Xanthan Gum, Triethanolamine, Sodium Phosphate, Octyldodecanol, Silica, Sodium Propoxyhydroxypropyl Thiosulfate Silica, Sodium Hydroxide, Caprylyl Glycol, Potassium Sorbate, Sodium Benzoate, Phenoxyethanol.

Peter Thomas Roth At-A-Glance

Peter Thomas Roth is a large but straightforward line with mostly uncomplicated formulations that, for the most part, are quite good and state-of-the-art. Unlike many product lines, most of the acne, AHA, BHA, sunscreen, and moisturizing products contain what they should to be effective and helpful for skin.

Even more impressive are the well-formulated cleansers, sunscreens, AHA products, and skin brighteners. The moisturizers have improved somewhat, and most are now packaged so that the light- and air-sensitive ingredients remain stable. In fact, Roth's packaging deserves special mention because it is exceptionally utilitarian.

After all that glowing praise, what you should be aware of are the instances of products containing potential irritants (noted in their respective reviews) as well as the products in jar packaging that contain ingredients which are sensitive to air and light.

For more information about Peter Thomas Roth, call (800) PTR-SKIN or visit www.peterthomasroth.com.

About the Experts

The Beautypedia team consists of skin care and makeup experts personally trained by the original Cosmetics Cop and best-selling beauty author, Paula Begoun. We’re fascinated by skin care and makeup products and thrilled when they meet or exceed our expectations, but we’re also disappointed when they fail to perform as claimed, are wildly overpriced, or contain ingredients scientific research has proven can hurt skin.

Our mission has always been to help you find the best products for your skin, no matter your budget or preferences. Beautypedia’s thorough and insightful reviews cut through the hype and provide reliable recommendations for all ages, skin types, and skin tones.

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