Perricone ACNE RELIEF Retinol Treatment & Moisturizer
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Perricone MD Cosmeceuticals

ACNE RELIEF Retinol Treatment & Moisturizer

2.00 fl. oz. for $ 45.00
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Perricone MD’s ACNE RELIEF Retinol Treatment & Moisturizer claims to be a soothing, nourishing solution for breakouts, but the inclusion of one problematic ingredient means it’s anything but that!

Packaged in an opaque plastic bottle with a pump dispenser that protects its ingredients, as advertised, this lightweight lotion absorbs quickly – making it a good texture for the combination to oily skin it’s designed to treat.

The formula contains a good amount of niacinamide, a B vitamin which helps improve the appearance of enlarged pores and can help normalize skin’s oil production, which is always helpful when dealing with acne. There are also amino acids (citrulline and arginine), which help strengthen skin’s defenses, vitamin E for antioxidant benefit, and of course anti-aging retinol, which can help refine visibly enlarged pores as well. So far, it’s a good mix for acne-prone skin…

Unfortunately, this also contains a high amount of drying denatured alcohol. This ingredient pops up in a lot of acne-fighting products because of its ability to instantly “de-grease” skin, but it’s longer-term effects can lead to irritation and inflammation that make acne breakouts worse, not better (see More Info below for details). Those with acne-prone skin should especially avoid alcohol-based skin care products because they can actually increase oil production over time.

This means that while there are positive aspects to this product, it’s best to avoid it and instead select an alternative from our list of best acne treatments.

Note: Salicylic acid is listed here as an active ingredient, though Perricone doesn’t make any claims about it for this product, either on its website or on its packaging. At this amount – and with its pH (4.8, a bit above the optimal range of 3-4), it won’t have the exfoliating abilities to fight acne breakouts, though it can have soothing and hydrating properties. In this case, however, they’ll be fighting an uphill battle against the drying alcohol.

Pros:
  • Lightweight lotion texture is ideal for combination to oily skin.
  • Includes pore-refining niacinamide, skin-replenishing amino acids, and pore-unclogging retinol.
  • Packaged to protect its light- and air-sensitive ingredients.
  • Fragrance free.
Cons:
  • Contains a high amount of drying alcohol, which can make acne breakouts worse.
  • Is not gentle or calming as claimed.

More Info:

Alcohol-Based Skin Care Products: Research makes it clear that alcohol, as a main ingredient in any skin care product, especially one you use frequently and repeatedly, is a problem.

When we express concern about the presence of alcohol in skin care or makeup products, we’re referring to denatured ethanol, which most often is listed as SD alcohol, alcohol denat., denatured alcohol, or (less often) isopropyl alcohol.

When you see these types of alcohol listed among the first six ingredients on an ingredient, the product is highly likely to irritate and cause other problems for skin; it doesn’t take much of this type of alcohol to trigger skin stress. There’s no way around it—these volatile alcohols are simply bad for all skin types.

The reason they’re included in products is because they provide a quick-drying finish, immediately degrease skin, and feel weightless, so it’s easy to see their appeal, especially for those with oily skin. If only those short-term benefits didn’t lead to negative long-term outcomes.

Using products that contain these alcohols will cause dryness, erode skin’s protective barrier, and a strain on how skin replenishes, renews, and rejuvenates itself. Alcohol just weakens everything about skin.

The irony of using alcohol-based products to control oily skin is that the damage from the alcohol can actually lead to an increase in breakouts and enlarged pores. As we said, the alcohol does have an immediate de-greasing effect on skin, but it causes irritation, which eventually will counteract the de-greasing effect and make your oily skin look even more shiny.

There are people who challenge us on the information we’ve presented about alcohol’s effects. They often base their argument on a study in the British Journal of Dermatology (July 2007, pages 74–81) that concluded “alcohol-based hand rubs cause less irritation than hand washing….” But, the only thing this study showed was that alcohol was not as irritating as an even more irritating hand wash, which contained sodium lauryl sulfate. So, the study is actually just telling you that one irritant, sodium lauryl sulfate, is worse than another irritant, alcohol.

Not all alcohols are bad. For example, there are fatty alcohols, which are absolutely non-irritating and can be beneficial for skin. Examples that you’ll see on ingredient labels include cetyl alcohol, stearyl alcohol, and cetearyl alcohol, all of which are good ingredients for skin. It’s important to differentiate between these skin-friendly alcohols and the problematic alcohols.

What about very low levels of denatured alcohol? These sometimes show up in products because the alcohol may be part of the preservative system or may have been used to make certain ingredients more soluble in the formula. In these instances the amount of alcohol is typically below 0.1%, so is unlikely to pose a risk to skin.

References for this information:
Journal of Hospital Infection, August 2019, pages 419-424
International Journal of Cosmetic Science, April 2017, pages 188-196
Drug Design, Development and Therapy, November 2015, pages 6,225-6,233
Toxicology and Applied Pharmacology, November 2014, pages 109-117
The Journal of Allergy and Clinical Immunology in Practice, March 2013, pages 195-196
Chemical Immunology and Allergy, March 2012, pages 77–80
Aging, March 2012, pages 166–175
Journal of Occupational Medicine and Toxicology, November 2008, pages 1–16
Dermato-Endocrinology, January 2011, pages 41–49
Experimental Dermatology, June 2008, pages 542–551
Clinical Dermatology, September-October 2004, pages 360–366
Alcohol Journal, April 2002, pages 179–190

Not being gentle to skin can increase oily skin & breakouts: Using harsh, irritating ingredients or cleansing brushes with stiff bristles is a serious problem for all skin types, especially for those with oily, combination, and acne-prone skin.

Research has clearly established that when skin is irritated, the oil gland at the base of each pore is stimulated to make more oil, creating a perfect environment for breakouts, white bumps, and clogged pores to get worse.

Using a product that is gentle and completely non-irritating is without question the only approach to taking the best care of your skin; doing otherwise hurts your skin—this is true even if you cannot see or feel the damage taking place.

It is also vitally important to use products that research has shown are beneficial for oily skin, clogged pores, and breakouts. The gold standard over-the-counter ingredients for these concerns are salicylic acid (BHA) and benzoyl peroxide.

References for this information:
Journal of Clinical Aesthetic Dermatology, January 2016, pages 25–30
Journal of European Dermatology and Venerology, May 2014, pages 527–532
Journal of Dermatology, May 2012, pages 433–438
Clinical, Cosmetic, and Investigational Dermatology, April 2011, pages 41–53
Dermato-Endocrinology, January-March 2011, pages 41–49
Experimental Dermatology, October 2009, pages 821–832
Journal of the American Medical Association, August 2004, page 764
Dermatology, January 2003, pages 17–23
European Journal of Dermatology, September-October 2002, pages 422–427

Jar Packaging: No
Tested on animals: No

The Retinol Treatment & Moisturizer is Step 2 in your night regimen, after cleansing. The lightweight yet nourishing formula absorbs instantly to control excess oil and helps to heal blemishes while you sleep without over-drying the skin. The powerful combination of retinol, citrulline and niacinamide helps to accelerate surface skin exfoliation and renewal, visibly calm skin and reduce redness, while gently and visibly erasing imperfections overnight.

Active ingredient: Salicylic Acid 0.5%. Inactive Ingredients: Water/Aqua/Eau, SD Alcohol 40-B, Glycerin, Dicaprylyl Ether, Niacinamide, Citrulline, Arginine, Methyl Gluceth-20, Cetearyl Alcohol, Carbomer, Xanthan Gum, Tocopheryl Acetate, Retinol, Citric Acid, Sodium Hydroxide, Disodium EDTA, PEG-20 Methyl Glucose Sesquistearate, PEG-100 Stearate, Glyceryl Stearate, Methyl Glucose Sesquistearate, Polysorbate 20, Phenoxyethanol, Sodium Benzoate, Potassium Sorbate.

Perricone MD CosmeceuticalsAt-A-Glance

Strengths: A handful of good cleansers; a couple of worthwhile moisturizers for the eye area; several fragrance-free products; a few impressive makeup products.

Weaknesses: Expensive; long on claims not supported by evidence-based science; use of controversial ingredients throughout the line; several antioxidant-rich products are packaged in jars, which renders those beneficial ingredients less effective.

This dermatologist-developed line is perhaps the best known in an increasingly crowded field. The frenzy began with Nicholas Perricone's first book, The Wrinkle Cure, and continued when he appeared on PBS to discuss his book and namesake products, all of which seemed incredibly legitimate to consumers worried about how to look younger longer. PBS reaped a financial windfall from his appearance, netting millions of dollars between 2001 and 2002 (Source: www.quackwatch.org). Originally all the fuss centered around vitamin C and alpha lipoic acid, but as his success continued, Perricone wrote half a dozen more books and expanded his product line to include other over-hyped ingredients, each with claims (and price tags) more inflated than the last round.

We sourced the Web site Quackwatch.org because they have an excellent, unbiased report on the Perricone phenomenon. This non-profit site is operated by consumer advocate Dr. Stephen Barrett, and, to quote the Quackwatch Mission Statement, their purpose is "to combat health-related frauds, myths, fads, fallacies, and misconduct." That's where Perricone comes into play. According to Quackwatch, Perricone's books "contain many claims that are questionable, controversial, fanciful, unsupported by published evidence, or just plain wrong. Although he mentions standard skin-care treatments, sometimes favorably, his books provide little guidance about when they might be appropriate or sufficient. Although he provides long lists of references, practically none of them directly support what he promises." Those sentiments are exactly what we felt and wrote after reading The Wrinkle Cure.

The site goes on to state: "Perricone's books are sprinkled with statements that his ideas are based on his own research. However, the extent and quality of this research is unclear. A PubMed search for his name brought up only six citations, of which only two appear to be original research, both on topical glycolic acid. His books describe situations in which he tested various ideas in a few patients, usually over a short period of time, but he provides few details and apparently published none of those findings in medical journals." Does that sound like the kind of products you'd like to spend (a lot of) your money on?

They go on to conclude (and we agree completely with the following text): "Dr. Perricone has mixed a pinch of science with a gallon of imagination to create an elaborate, time-consuming, expensive, prescription for a healthy life and younger skin. There is no reason to think his program is more effective than standard measures. Although some of his advice is standard, most of his recommendations are based on speculation and fanciful interpretation of selected medical literature. He makes lots of money by convincing patients and consumers, but he hasn't succeeded in convincing critical thinkers, doctors, scientists, or anyone who wants to see hard evidence. Perricone's prescription isn't science; it's creative salesmanship." And which ingredient is the answer for healthy skin? Perricone can't seem to make up his mind, because one group of products contains alpha lipoic acid, another group olive oil, another vitamin C, and still another neuropeptides. Come on, doctor, which is it?

One ingredient Perricone uses deserves some discussion because it is present in all of his products, and that's dimethyl MEA, also known as DMAE (chemically 2-dimethyl-aminoethanol). DMAE has been around for years as an oral supplement that's popularly believed to improve mental alertness, much like Ginkgo biloba and coenzyme Q10. However, the research about DMAE does not show the same positive results as the other two supplements. Because DMAE is chemically similar to choline, DMAE is thought to stimulate production of acetylcholine. And because acetylcholine is a brain neurotransmitter, it's easy to see how it could be associated with brain function. However, only a handful of studies have looked at DMAE for that purpose and they have not been conclusive in the least, while some have shown that DMAE may be problematic or not very effective (Sources: Mechanisms of Aging and Development, February 1988, pages 129138; Neuropharmacology, June 1989, pages, 557561; European Neurology, 1991, pages 423425; and European Journal of Medical Research, May 2003, pages 183191).

How does any of this translate into skin care, or, more to the point, suppressing the signs of aging? Perricone claims DMAE restores muscle tone to skin that has lost firmness and has begun to slacken, as well as conveying an antioxidant benefit. Johnson & Johnson uses DMAE in a few of their Neutrogena products, and a study they paid for appeared in the American Journal of Clinical Dermatology (June 2005, pages 3947). The conclusion was as follows: "the benefits of DMAE in dermatology include a potential anti-inflammatory effect and a documented increase in skin firmness with possible improvement in underlying facial muscle tone." The study examined topical application of 3% DMAE over a period of 16 weeks, but it was not done double-blind and was not placebo-controlled, which makes the results, at best, questionable. Moreover, the study didn't examine whether a 3% or lower concentration of other ingredients, such as green tea, glycolic acid, vitamin C, or myriad others (many of which Perricone has extolled in his other products, and the amount of DMAE he used varies widely from product to product), might have had the same or better results.

Is there any reason to get excited (and drain your pocketbook) for products with DMAE? Apparently not; a study published in The British Journal of Dermatology (May 2007) has shown contrary evidence that it may actually pose risks for the skin. In vitro tests of the pure substance, as well as creams that contained DMAE, demonstrated a fairly fast and significant increase in protective elements around the skin cell. However, a short time later the researchers observed an important reduction in cell growth and in some cases they found that it halted cell growth altogether. So, while you may initially experience a kind of swelling of the skin because of the expanding effect caused by topical application of DMAE, the long-term results appear to be far from desirable.

Interestingly, even though this ingredient is present throughout Perricone's line, he has yet to publish his own research discussing the claims and explaining how topical DMAE works. The bottom line is that as more research comes to light, DMAE may prove more problematic than helpful for aging skin. But in the meantime, Perricone is raking in lots of money by convincing consumers otherwise.

For more information about Perricone MD Cosmeceuticals call (888) 823-7837 or visit www.perriconemd.com.

About the Experts

The Beautypedia team consists of skin care and makeup experts personally trained by the original Cosmetics Cop and best-selling beauty author, Paula Begoun. We’re fascinated by skin care and makeup products and thrilled when they meet or exceed our expectations, but we’re also disappointed when they fail to perform as claimed, are wildly overpriced, or contain ingredients scientific research has proven can hurt skin.

Our mission has always been to help you find the best products for your skin, no matter your budget or preferences. Beautypedia’s thorough and insightful reviews cut through the hype and provide reliable recommendations for all ages, skin types, and skin tones.

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